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Human motor neurones: so well-known or still unknown?
Movements, the fundamental base of normal human life, are produced when our skeletal muscles contract and relax, submitting to control by special nervous cells, the so-called motor neurones...
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Tapping neurotransmitters from neurons to investigate their involvement in...
To tap neurotransmitters and neuromodulators from brain neurons of anaesthetised rodents, a guide cannula is stereoractically inserted. Into a distinct brain structure. Few days after surgery the...
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Microtubules slide neurons home
Brain development requires neurons, the most sophisticated information-carrying cells in the body, to migrate from where they are born to faraway destinations where they finally settle down and take up...
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Serotonin and sleep regulation: cellular and molecular mechanisms
Serotonin ( 5-HT ) is a neurotransmitter, which plays major roles in several physiological functions including circadian rhythmicity, appetite, thermoregulation, nociception, emotion and cognition. The...
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Five distinct neuronal types inhabit the ventrolateral preoptic nucleus
The ventrolateral preoptic nucleus (VLPO) is considered as the main brain region inducing slow-wave sleep (SWS). Despite its physiological importance, the neuronal composition of the VLPO still...
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Reversibility of Aβ oligomer neurotoxicity: Insights into the treatment of...
Alzheimer’s disease (AD), the most common neurodegenerative dementia disorder, causes memory impairment and other cognitive deficits. AD is neuropathologically characterized by senile plaques and...
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New psychoactive substances: metabolites of synthetic cathinones induce...
Recently, a large number of novel psychoactive substances (NPSs) have appeared on the European market. Their growing diffusion has become matter of worldwide concern and alarm for public health...
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Ketamine, not TPS potentiates glutamate-induced Ca neurotoxicity
There is growing concern about anaesthesia effects on the developing brain because commonly used anaesthetics can cause neurodegeneration and long-term neurocognitive deficits. In the developing brain,...
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HIV-1 alters mitochondria in neurons and contributes to HIV-associated...
Human immunodeficiency virus type-1 (HIV) enters the brain during the initial stages of infection and can cause neurologic dysfunction. Despite the success of HIV treatment through combination...
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Matching between adult neurons: feel abandoned? Just call on me
Plasticity in the central nervous system allows the adaptation of neural circuits to new circumstances, such as the recovery after brain injury. The mechanisms of neural plasticity include, among...
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